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What are the advantages of the High Shear Mixer Granulators?

Views: 42     Author: Site Editor     Publish Time: 2022-04-11      Origin: Site

Introduction for the high shear mixer granulator

If you are in the pharmaceutical or chemical industry, you are likely aware of the importance of high-shear mixer granulators. These machines are used for wet granulation, which is a process that involves the creation of granules from powders. In this article, we will discuss the advantages of high-shear mixer granulators and why they are a crucial tool for any pharmaceutical or chemical manufacturing operation. 

A high shear mixer granulator is the most critical equipment in the solid preparation production line. Hywell Pharmaceutical Granulation Line for solid dosage forms, includes High Shear Mixer granulator, Wet granulator, Fluid Bed Dryer, Lifting Column, Conical Mill, Vacuum Conveying System, Blender, etc.


What is a High Shear Mixer Granulator?

A high-shear mixer granulator is a machine that combines several processes into one unit operation. It is primarily used for wet granulation, which is a process that involves the mixing of powders with a liquid binder to form granules. The high-shear mixing granulator is equipped with an impeller and a chopper that work together to create a homogeneous mixture of powders and liquids. The impeller generates a high shear force, while the chopper breaks down any lumps and ensures a uniform particle size distribution.


High Shear Mixer Granulator Video


Advantages of High Shear Mixer Granulators

Efficient Granulation Process

High-shear mixer granulators are highly efficient when it comes to granulation. They are designed to produce uniform and consistent granules in a short amount of time. This is because the impeller generates a high shear force that promotes the formation of agglomerates, which are then broken down by the chopper. As a result, the granulation process is completed quickly and efficiently.


Homogeneous Granules

One of the primary advantages of high-shear mixer granulators is that they produce homogeneous granules. The impeller and chopper work together to ensure that the powders and liquids are evenly distributed throughout the mixture. This results in granules that have a uniform composition and density.


Consistent Particle Size Distribution

High-shear granulators are also capable of producing granules with a consistent particle size distribution. The impeller and chopper work together to break down any lumps and ensure that the granules are of the same size. This is important for applications that require a specific particle size distribution.


High Productivity and Reduced Processing Time

High-shear mixer granulators are designed to be highly productive. They are capable of producing large quantities of granules in a short amount of time. This is because the granulation process is completed quickly and efficiently, which reduces processing time and increases productivity.


Improved Powder Flowability

Powder flowability is a critical factor in many manufacturing processes. High-shear mixer granulators are capable of improving powder flowability by breaking down any lumps and ensuring a uniform particle size distribution. This results in powders that are easier to handle and transport.


Enhanced API Content Uniformity

High shear mixer granulators are also beneficial in pharmaceutical manufacturing, as they ensure that the active pharmaceutical ingredient (API) is evenly distributed throughout the granules. This leads to enhanced API content uniformity and ensures that each tablet or capsule contains the correct amount of the API.


Low Shear Force and Reduced Frictional Heat

High shear mixer granulators are designed to generate a low shear force, which reduces frictional heat. This is important in pharmaceutical manufacturing, as it helps to prevent the degradation of heat-sensitive materials. The low shear force also helps to minimize dust generation, which is critical in cleanroom environments.


Easy Scale-up and Down

High-shear mixer granulators are also designed to be easily scalable. This means that they can be used for both small-scale and large-scale manufacturing processes. it also has lab model high shear granulators from 3L to 20L The equipment can be easily adjusted to meet the specific needs of each manufacturing process, making it a flexible and versatile tool.


Flexibility and Versatility

High shear mixer granulators are also flexible and versatile, as they can be used for a variety of applications. They can be used for wet granulation, dry granulation, powder mixing, and coating. This versatility makes them a valuable tool in any pharmaceutical or chemical manufacturing operation.


GMP Compliance and Validation

High shear mixer granulators are designed to meet Good Manufacturing Practice (GMP) standards. This means that they are manufactured to the highest quality standards and are suitable for use in pharmaceutical manufacturing. They are also easy to validate, which is critical in regulatory environments.


High Shear Mixer Granulator Characteristic

1. The High Shear Mixer Granulator have the excellent homogeneity of mixing with no dead points

2. The High Shear Mixer Granulators have the Complete discharge and easy cleaning

3. The High Shear Granulator is safety cage to prevent human injury

4.  Mixing in independent containers (Laboratory High Speed Mixers have this function) offers no contamination and emissions, no extra cleaning.

5. Time-saving, fast exchange of the container (on small models as an Option), due to simple and fast mounting of the container

6. Highly polished inner and outer surfaces of the barrel, no dead comer, easy to discharge materials, easy to clear, no cross contamination. Confining to the requirement of GMP.

7. The super mixing granulator have the Low noise and good seal

8. The high mixer granulator have enclosed structure, without overflow of power dust

9. The super mixing granulators have smooth running, reliable performance, easy operation.

10. The super blending granulator have small cubage, easy to install, convenient to operate and maintain.

11. The time of mixing in dry is 2 minutes and the time of granulating is 1-4 minutes. Compared with the traditional process, 4-5 times of efficiency is raised;

12. In the same sealed container, dry mixing, humidity mixing and granulating can be finished, it is in conformity with the requirements of GMP;

13. One- step accomplished in one equipment

14. The interval between the bowl and impeller is controlled to be within 1mm

15. Granulation process requires less bind

16. Granulation is achieved within a short time

17. Greater densification and production of less friable granules

18.  The food granulator produces reproducible less friable granules with a uniform particle size distribution

19.  High shear mixer minimizes the exposure of drug dust to workers due to reduced process dust generation

20.  The granulation endpoint is predictable while using a high shear mixer

21.  the high speed granulator machine can be saving 25% of adhesives and drying time

22.  The food granulating machine can be equipped with cone mill or swing granulator

23. Connect with fluid bed dryer by vacuum conveying by vacuum conveying.

24. The food high shear granulator have the automatic PLC control system, mixing, granulating and milling


super blending granulator machine

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