Lab Solid Dosage Manufacturing Line – Wet Granulation Process

Solid Dosage Manufacturing Line – Wet Granulation Process is an integrated granulation and drying solution designed for pharmaceutical solid dosage form production. This pharmaceutical wet granulation line is widely used in tablet and capsule manufacturing, where high standards of content uniformity, bulk density, and physicochemical stability are required.

In solid dosage manufacturing, selecting the correct wet granulation process line is critical to product quality and process consistency. The high shear wet granulation and fluid bed drying system converts fine, heterogeneous powder blends into uniform, free-flowing granules with controlled particle size distribution and improved density. This integrated solid dosage wet granulation line ensures reproducible granule quality, efficient downstream processing, and full compliance with GMP requirements.

Model:
GL
Brand:
HYWELL
Code:
8479899990
Material:
SUS304/SUS316L/Titanium
Application:
Food/Pharmaceutical/Chemical

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Quantity:



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Product Description

Integrated Lab-Scale Wet Granulation Process for Solid Dosage Manufacturing

The Lab Solid Dosage Manufacturing Line – Wet Granulation Process from Hywell is a compact, single-frame solution designed for laboratory and pilot-scale pharmaceutical applications. It integrates all critical steps of the wet granulation process into one flexible and efficient system, supporting formulation development, process optimization, and scale-up studies.

The integrated manufacturing line typically consists of a High Shear Granulator for powder mixing and wet granulation, a Fluidized Bed Dryer for efficient drying with optional granulation or coating functions, and a dry granulation (calibration) unit for post-drying particle size control. After calibration, the finished granules are transferred via negative-pressure vacuum conveying directly into the final product blender, ensuring a fully enclosed and dust-free process. By integrating these key units on a single platform, the lab-scale solid dosage wet granulation line significantly reduces cleanroom space requirements, minimizes manual handling, and effectively lowers the risk of cross-contamination, product loss, and operator error, while fully complying with GMP and pharmaceutical process standards.

The lab solid dosage granulation line is available in capacities ranging from 30 L to 50 L, allowing seamless transition from laboratory research to pilot and small production batches. The system supports wet granulation, in which a binder solution is added to a powder blend to form granules with controlled size, density, and flow properties. The high-shear action ensures uniform binder distribution and consistent granule formation within specified limits.

Following granulation, the wet granules are transferred to the Fluidized Bed Dryer, a widely used drying technology in pharmaceutical laboratories. In this process, conditioned hot air is introduced through a perforated product container at a controlled flow rate and pressure. The moist particles are fluidized and suspended in the air stream, enabling efficient heat and mass transfer through direct contact between the hot air and the wet solids. The evaporated moisture is continuously removed by the exhaust air, resulting in uniform and gentle drying.

Lab Solid Dosage Manufacturing Line – Wet Granulation Process

Lab Solid Oral Dosage Granulator Line

The Lab Solid Dosage Manufacturing Line – Wet Granulation Process is a premium, integrated pharmaceutical solution designed for laboratory and pilot-scale solid oral dosage manufacturing. This advanced wet granulation line combines mixing, wet granulation, drying, and final blending into a closed and controlled system, ensuring high product quality, process repeatability, and zero cross-contamination in compliance with GMP requirements.

The Hywell Machinery lab solid dosage manufacturing line adopts automatic PLC control with an intuitive HMI interface, allowing operators to set, monitor, store, review, and print process parameters. This ensures full process traceability, data integrity, and reproducibility, which are critical for laboratory studies and scale-up validation.

An integrated CIP (Clean-in-Place) system provides efficient and validated cleaning for both the granulator and the fluidized bed dryer, ensuring fast product changeover and compliance with pharmaceutical hygiene standards. In addition, explosion-proof design, reliable safety interlocks, and proper grounding systems ensure maximum protection for personnel, equipment, and the production environment.

Hywell Machinery specializes in providing custom lab-scale wet granulation manufacturing lines tailored to specific process requirements and user specifications. The system is suitable not only for pharmaceutical applications, but also for food, nutraceutical, and fine chemical industries. Regardless of location, Hywell offers global support and even enables customers to order lab solid dosage granulation lines online.

Lab Solid Dosage Granulators Line Specifications

Model	GL-5	GL-10	GL-15
Capacity	5	10	15
Equipment composition	HS-3	HS-3	HS-3
	GHL-20	GHL-30	GHL-50
	GZL-20	GZL-20	GZL-20
	FG-50	FG-100	FG-15
	HS-3	HS-3	HS-3

Lab Solid Dosage Manufacturing Line Composition

Nowadays, laboratory solid dosage manufacturing lines play an increasingly important role in formulation development, process optimization, and small-scale validation for pharmaceuticals, health products, food, and fine chemicals.

With more than 20 years of experience in solid processing technology, Hywell focuses on integrated granulation and drying solutions specifically designed for laboratory and pilot-scale solid dosage manufacturing.

Hywell Lab Solid Dosage Manufacturing Line

The Hywell Lab Solid Dosage Manufacturing Line is a compact and highly integrated system. Based on our actual equipment configuration, the integrated unit includes:

Wet Mixing Granulator (High Shear Mixer Granulator)
Wet Sizing Mill (Wet Granulator)
Fluid Bed Dryer (Boiling Dryer)
Dry Sizing Mill (Dry Granulator)
Vacuum Conveying System
Powder Mixer

All equipment is designed to work as one integrated line, ensuring efficient, enclosed, and flexible laboratory operation.

Process Description

The wet mixing granulator and wet sizing mill are installed as an integrated unit. After wet granulation, the wet granules are directly transferred by vacuum conveying into the fluid bed dryer for efficient and uniform drying.

After drying, the material is discharged into the dry sizing mill to obtain the required particle size distribution. Finally, the dried granules are transferred to the powder mixer to ensure excellent homogeneity before further processing or tableting/capsule filling.

Advantages of the Lab Line

Compact, integrated design suitable for laboratory and pilot plants
Fully enclosed process with vacuum conveying, minimizing cross-contamination
Flexible configuration for R&D, scale-up studies, and formulation trials
One integrated system covering wet granulation → drying → milling → mixing

As a professional manufacturer of lab and pilot solid dosage wet granulation systems, Hywell provides reliable, scalable, and cost-effective solutions that closely simulate industrial production processes, making them ideal for formulation development and process validation.

Lab Solid Dosage Process Material

Hywell Machinery can offer our Lab Solid Dosage Process with product contact parts manufactured in SS304, SS316L, Titanium, Duplex stainless steel, and other suitable materials. The electrical components and control system of the Lab Solid Dosage Process can be fully customized and adapted to meet the specific requirements and standards of the customer.

Our services

Our pre-sales and after-sales services make it easy for customers to acquire and use our granulation processing equipment.

Our engineers can offer assistance during regular equipment maintenance, provide fluid bed granulation troubleshooting, and even handle on-site repairs.

We also offer training for operators to help them maximize your factory’s efficiency.

Contact Us

Reach out to our professional support team by sending a request on our contact page, and tell us more about your needs. You can also send an email to sales@hywellco.com or call us at +86-13382828213