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Why does the high shear mixers granulator important?

Views: 17     Author: Site Editor     Publish Time: 2022-04-06      Origin: Site

Why does the high shear mixers important?

The advent of high shear mixer granulators also called rotor/stator mixers revolutionized mixing technology. Imparting vigorous radial and axial flow patterns and intense shear, Hywell machinery Rapid Mixer Granulators accomplish a variety of processing objectives including homogenization, emulsification, powder wet-out, and agglomeration.

Hywell machinery is leading High Shear Inline Mixers granulators manufacturer are used throughout many industries, including the pharmaceutical, health product, food, cosmetics, and chemicals industries. For challenging applications, Hywell machinery also offers advanced rotor/stator configurations: Ultra-High Shear Mixers capable of producing very fine emulsions and dispersions.

Hywell Machinery uses innovative solid dosage production process for High-Speed Mixers

High shear mixer granulation is an innovative solid dosage production platform designed to achieve operational excellence in the pharmaceutical manufacturing Industry. Raw materials are converted into final dosage forms in development, pilot, clinical and production volumes using wet granulation in one continuous production line. Hywell Machinery high shear homogenizer, offer the outstanding advantages of efficiency and product uniformity achieved with shearing mixing.

super shear mixer

The high-shear mixer granulator is important for several reasons:

1.  Uniform Mixing

It ensures thorough mixing of ingredients, resulting in a homogeneous mixture. This is crucial for the even distribution of active pharmaceutical ingredients (APIs) and excipients in pharmaceutical formulations, ensuring consistent drug potency and efficacy.

2. Particle Size Reduction

The granulator's high-shear mixing action helps break down agglomerates and achieve the desired particle size distribution. This is essential for producing granules with uniform size and shape, which affects the drug release profile and overall product quality.

3. Granule Formation

It facilitates the formation of granules by agglomerating fine powder particles into larger, free-flowing granules. This improves the handling characteristics of the product during subsequent processing steps such as tableting or encapsulation.

4. Controlled Granulation Process:

The high-shear mixer granulator allows for precise control over parameters such as mixing speed, impeller design, and liquid binder addition rate. This enables the optimization of granulation conditions to meet specific product requirements and ensures reproducibility batch after batch.

5. Enhanced Dissolution Rate

By promoting uniform distribution of APIs within the granules and reducing particle size variability, the high-shear mixer granulator can improve the dissolution rate of drugs, leading to faster and more consistent drug absorption in the body.

Overall, the high-shear mixer granulator plays a critical role in the pharmaceutical manufacturing process by facilitating efficient mixing, granule formation, and particle size control, ultimately contributing to the quality, efficacy, and performance of the final dosage forms.

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